Figure 1: Crystal structure of Cas9 in complex with a sgRNA and a PAM- containing target DNA. Figure 3: Interactions with the +1 phosphodiester group orient the target strand for guide-RNA binding.

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team. DNA is widely accepted to be formed of two strands that wind around one ...

The story familiar to most people involves how James Watson and Francis Crick discovered the structure of DNA, cementing their place in scientific history. But Merkel's book paints a more ...