As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

An Osaka Metropolitan University-led study demonstrated that Cdc42 (cell division cycle 42) plays a crucial role in the formation and maintenance of the morphological characteristics of quiescent ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years.

New research demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor-fibroblasts ...

Scientists at Massachusetts General Hospital have revealed how chronic liver injury alters hepatic stellate cells (HSCs), triggering the formation of fibrotic scarring in the liver. The researchers ...

Parkinson's doesn't just affect movement and the brain—it may also impact the heart, according to new research from the ...

The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.