C2C12 cells were infected with adenovirus expressing Notch1 ICD-IRES-EGFP, Notch3 ICD-IRES-EGFP, Hes1, Hey1, or EGFP (Ad-Notch1 ICD, Ad-Notch3 ICD, Ad-Hes1, Ad-Hey1, and Ad-EGFP, respectively) at a ...

JNJ-79635322 shows favorable responses and manageable safety in BCMA/GPRC5D-naïve patients with relapsed/refractory multiple ...

G protein–coupled receptors (GPCRs) are a protein superfamily comprising >800 members that regulate numerous cellular and physiologic responses. GPCRs represent the largest class of therapeutic ...

A total of 73 patients diagnosed with LM were treated with osimertinib, including 64 patients evaluable for the LM efficacy set—T790M negative (n = 62) and T790M positive (n = 2). The median OS in the ...

Researchers found a small, specialized group of nerve cells in the hypothalamus that influence hunger and weight gain. These ...

The global neuroendocrine carcinoma treatment market is likely to generate revenue amounting to USD 1,976 million in 2024. Over the assessment period, the industry is projected to expand at an 8.1% ...

Shuttle-based therapies are under active development for an array of brain conditions. “It’s now abundantly clear that we can ...

A research group has identified the so-called PNOC/NPY nerve cells in the brains of mice. When activated, these cells ...

Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful ...

The research team demonstrated that innate immune cells called Natural Killer (NK) cells that express CD8a on the cell ...

Obesity is a global health problem that affects many people. In recent years, very promising anti-obesity drugs have been developed. Despite these successes, there are patients who do not respond to ...

There is no highly effective vaccine against tuberculosis (TB), which remains an infection of global concern. Charles ...