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pharmaphorum2d
Innovation in generics: Increased efficiency through peptide API synthesis expertise
Peptide APIs are manufactured via a series of chemical reactions assembling a chain from monomeric components. The most common synthesis routes consist of either solid-phase peptide synthesis ...
ascopubs.org1d
Updated Survival Follow-Up for Phase Ib Trial of the Histone Deacetylase Inhibitor Abexinostat With Pazopanib in Patients With Solid Tumor Malignancies
Safety and Efficacy of Osimertinib in Patients With Non–Small-Cell Lung Cancer and Uncommon Tumoral Epidermal Growth Factor Receptor Mutations: A Systematic Review and Single-Arm Meta-Analysis ...
ascopubs.org3d
Phase I study of peptide vaccine targeting indeolamine 2,3 dioxygenase in metastatic lung cancer patients.
A retrospective analysis of the prevalence of EGFR or KRAS mutations in patients (pts) with crizotinib-naïve and crizotinib-resistant, ALK-positive non-small cell lung cancer (NSCLC). Incidence, ...
C&EN19d
Organic Solvent Nanofiltration: A New Paradigm in Peptide Synthesis
Find more information on the Altmetric Attention Score and how the score is calculated. Solid-phase synthesis is the dominant paradigm for peptide synthesis, used ubiquitously from discovery to ...
C&EN3d
Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N -Acetylgalactosamine Clusters
Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
Cancer Research29d
PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform: Phase I Study in Patients with Solid and Hematologic Malignancies in the Adjuvant Setting
1Vaccine and Cell Therapy Laboratory, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. 2Division of Hematology Oncology, Department of Medicine, Tisch Cancer ...
BMJ28d
A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours
This phase I trial (NCT03853109) evaluated the safety, pharmacokinetics (PK) and antitumour activity of AMG 404 in patients with advanced solid tumours. Herein, we report the primary analysis of the ...