This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Beaupre, M.D., Ph.D., Chief Medical Officer, IDEAYA Biosciences. IDE849 is in an ongoing multi-site open label Phase 1 clinical trial for advanced solid tumors (NCT06443489) by Jiangsu Hengrui ...

About the Phase 2 Study of AU-007 AU-007 is being investigated in a phase 1/2 open-label, dose-escalation and -expansion study. Phase 1, which evaluated AU-007 as a monotherapy, with a single loading ...

Tagworks initiated first-in-human phase 1 clinical development of TGW101 in a multicenter, open-label, dose-escalation trial in patients with advanced solid tumours. The primary objectives of the ...

We found that arginine limitation in pancreatic tumors perturbs saturated and monounsaturated fatty acid synthesis by suppressing the lipogenic transcription factor SREBP1. Synthesis of these fatty ...

Mechanistically, Rbm24a interacts with the germ plasm component Buc to dictate the specific recruitment of germ plasm mRNAs into phase-separated condensates. Germ plasm particles lacking Rbm24a and ...

Therapeutic antisense oligonucleotides can modulate target gene expression with high specificity through various mechanisms determined by base sequences and chemical modifications; and have shown ...

This resin has previously reported for the synthesis of cyclo thiodepsipeptides and homodetic ... which was then centrifuged and decanted. The remaining solid was dissolved in CH 3 CN-H 2 O (1:1) and ...