Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

(A) PQSs in the single strands are easier to be induced into G4s ... PQS1m-sgRNA-a and PQS1m-sgRNA-a were used as primers to synthesize guide DNA, and then, guide RNA (sgRNA) was obtained by reverse ...

This research investigates how to optimize mRNA transfection in human T-cells utilizing the jetMESSENGER ® transfection reagent ... setting the standards for single-use products that are ...

A start-up that launched only 8 months ago has attracted the attention of Biogen, a major developer of neurological drugs.

Ribosome research has been a critical field of study since the 1960s, focusing on these essential intracellular organelles responsible for protein synthesis ...