Cellular communication is a critical process that relies on exocytosis, during which cells release stored chemical messengers contained within intracellular nanoscale vesicles (50–500 nm in diameter).

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

Given the contribution of EC-derived EVs to atherosclerosis, this model represents the first in vivo murine approach to tracking intercellular EC-EV communication within the plaque. It provides an ...

Vesicles are small blisters that can appear on your skin. They can be a symptom of a medical issue or a sign of tissue injury. Some conditions, like contact dermatitis or cold sores, may not ...

They tracked LIMP-2 and GCase in HEK cells. In COMMD3 knockouts, these proteins were captured by post-Golgi vesicles, some of which appeared to be early endosomes (image above). Examining ...

In large part, progress has been slow due to a scarcity of techniques for both (i) accurately quantifying composition-dependent properties of artificial cell models at the single-vesicle level and (ii ...

Methods: To elucidate the mechanisms associated with EBI-like activity we carried out a quantitative proteomic analysis and assessed the role of extracellular vesicles using Nanosight Tracking ...