This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

“If you can sample a vesicle, or any entity, from blood ... One approach involves developing an antibody that can detect the surface-exposed portion of LAT1. Although LAT1 is a surface marker, the ...

We tested the hypothesis that the bacterial extracellular vesicles (BEVs) from Gram-negative bacteria ... The microbial communities in the human body each generate BEVs as part of the secretory ...

Secretory vesicles derived from the trans-Golgi undergo a complex cycle — including maturation, translocation, membrane docking, and fusion of a subpopulation of vesicles with the cell membrane — but ...

This study describes a comprehensive set of classical techniques in biochemistry and cell biology characterizing the unconventional secretory mechanism of α-synuclein, an important contributor to ...

the secretory response to 16.7 mM glucose was reduced by 40–68% in cells cultured under high glucose (p < 0.01) (Supplementary Figure 1). Restricted Fusion Pore, Delayed Opening, Vesicle Collapse, and ...