Sanofi is to buy Principia Biopharma for up to $3.68 billion ... give it full control of the brain-penetrant BTK inhibitor, SAR442168, making marketing more efficient and eliminating any royalty ...

Liver injuries also prompted the FDA to impose a partial clinical hold on Sanofi's BTK inhibitor tolebrutinib (SAR442168 ... of its $3.7 billion buyout of Principia Biopharma.

Mauk was named as the new head coach at Principia High in Town and Country, Missouri, near St. Louis, marking the first head-coaching job for the former Tiger. Principia announced the hire in a ...

The former Missouri quarterback was named the head coach of Principia on April 17. The Panthers were 1-9 in 2024. “I am incredibly honored to join the Principia community,” Mauk said.

The Tigers are going where they’ve never gone before: The final meet of the season, where they'll compete for a national title. Missouri gymnastics prolonged its season in a fight to the finish ...

Mr. Polonsky’s foundation also made it possible, in 2011, for the Cambridge University Library to digitize Isaac Newton’s early papers and an annotated first edition of his “Principia.” ...

Park Hill South 2026 guard Addison Bjorn was named 2024-2025 MBCA Class 6 All-State. / Photo by Nate Latsch, SBLive Now that the 2024-2025 high school basketball season has ended for Missouri ...

The Philosophiae Naturalis Principia Mathematica took Newton two years to write. It was the culmination of more than 20 years of thinking. It outlined his own theory of calculus, the three laws of ...

This is a phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS). SAR442168 (tolebrutinib) is ...

N Engl J Med 2025. DOI: 10.1056/NEJMoa2415988. 2. Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (HERCULES).