A crucial test of the aggregation hypothesis will be to determine whether all mouse lines expressing mutant forms of SOD1 lead to early formation of microscopic, biochemical aggregates.

Dokholyan explained that they introduced SOD1 trimers into three different types of mouse tissue—brain, spinal cord and ...

An active immunization protocol using recombinant SOD1 mutant protein was successful in delaying onset of disease and mortality in an ALS mouse model. Passive immunization through intraventricular ...

For example, active immunization with repeated injections of recombinant SOD1 mutant conferred substantial protection in ALS mice. Moreover, a passive immunization approach based on ...