For example, in studies involving SOD1 ASOs, we have seen knockdown effects lasting up to eight weeks after a single intrathecal injection. In a different case, with the C9orf72 mouse model ...

So in the case of the SOD1 program, in the initial time points ... where we inject human pathological tau into P301S transgenic mice. And so we want to be sure we exceed those, what the EC50 ...

Two different mice models have been largely used for the ... In particular, the recruitment of mutant SOD1 to spinal mitochondria is thought to be the basis for their selective toxicity in ALS.

Mouse anti-α-smooth muscle actin (SMA ... Rabbit anti-fatty acid synthesis (FASN), superoxide dismutase 1 or 2 (SOD1/SOD2), heat shock protein 90 (HSP90), and glyceraldehyde-3-phosphate dehydrogenase ...

[39] Soo, Atkin, Farg, Walker, Horne, and Nagley (2012) Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic ... striatal co-cultures from Huntington's disease ...

With curly whiskers and wavy, light hair that grows three times longer than that of an ordinary lab mouse, the genetically modified rodent embodies several woolly mammoth-like traits, according to ...

The University of Georgia has been at the forefront of research utilizing transgenic mice. These genetically modified mice are valuable in studying human diseases due to their genetic similarity ...

CINCINNATI — During a joint address to the United States Congress on Tuesday, President Donald Trump claimed the government has funded scientific studies aimed at "making mice transgender." ...

On Tuesday, Colossal announced that its scientists have simultaneously edited seven genes in mice embryos to create mice with long, thick, woolly hair. They nicknamed the extra-furry rodents as ...

A new study finds that mice will sniff, lick and pull the tongue of other mice that are under anesthesia, serving to open their airways Sara Hashemi Daily Correspondent A new study suggests lab ...