A crucial test of the aggregation hypothesis will be to determine whether all mouse lines expressing mutant forms of SOD1 lead to early formation of microscopic, biochemical aggregates.

Dokholyan explained that they introduced SOD1 trimers into three different types of mouse tissue—brain, spinal cord and muscle tissue—and observed which proteins attached to the trimers.

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You have full access to this article via your institution. Figure 1: (a-c) Apoptotic changes are absent in mutant SOD1 mice. Although we cannot definitely rule out that motor neuron death in ...

In mice, the drugs reduced the progression of MND, increased their survival rates, diminished levels of the unstable SOD1 protein and protected the motor neurons," Dr. Lum said. There are 150 ...