Proteins are the infinitely varied chemicals that make cells work, and science has a pretty good idea how they are made. But a critical aspect underlying the machinery of protein manufacture has long ...

The kinetic evidence suggests that the movement takes place after the ribosome has attained an unlocked conformation induced by EF-G and GTP hydrolysis 12, implying that tRNA movement is spontaneous.

During translation elongation, ribosome translocation along an mRNA entails rotations of the ribosomal subunits, swiveling motions of the small subunit (SSU) head and stepwise movements of the ...

Although decoding is globally analogous in both species, the reaction coordinate of aminoacyl-tRNA movement is altered on the human ribosome and the process is an order of magnitude slower.

When ribosomes go rogue Unusual variations in the cellular protein factory can skew development, help cancer spread, and more. But ribosome variety may also play biological roles, scientists say.

Mutated huntingtin protein found to slow brain cells' ribosomes and protein synthesis. Findings may pave a new way for the development of therapeutics.

This video shows the flexibility of the genetic adaptor molecule, transfer RNA (tRNA), as it transits the protein synthesizing factory, the ribosome. The ribosome translates the 4-letter genetic ...

This "action shot" reveals the motion of the small ribosomal subunit, depicted by difference vectors, during ratcheting. Ratcheting is required to move the tRNAs through the ribosome "assembly ...

How ribosomes shape the proteome Date: December 6, 2017 Source: University of Groningen Summary: Cells are crowded with macromolecules, which limits the diffusion of proteins, especially in ...

Ribosomes are “protein factories” in the cells of all living things. They produce proteins based on existing genetic codes stored on special nucleic acid molecules. These molecules, also ...