Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Find more information on the Altmetric Attention Score and how the score is calculated. We show that diffusion of single urease enzyme molecules increases in the presence of urea in a ...

The discovery of recombinant DNA proved that biology, not chemistry alone, could create new medicines like life-saving ...

National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China ...

In tumours these enzymes can be secreted, bind to specific regions on the cell membrane and are localized in endolysosomal vesicles. Their substrates and functions differ depending on their location.

ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers (ARBs) are equally guideline-recommended first-line treatments for hypertension, yet few head-to-head studies exist. We ...