News

eLife5d
Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...
TMCnet12d
Kanazawa University Research: Visualizing the Mechanics of Hormone-Driven Gene Activation: Insights into Breast Cancer
KANAZAWA, Japan, April 23, 2025 /PRNewswire/ -- Scientists at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University have captured real-time footage showing how a key hormone receptor ...
eLife13d
Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation
This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...
C&EN17d
Zooming into Gene Activation: Estrogen Receptor α Dimerization and DNA Binding Visualized by High-Speed Atomic Force Microscopy
Division of Nano Life Science in the Graduate School of Frontier Science Initiative, WISE Program for Nano-Precision Medicine, Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920-1192, ...
The EMBO Journal18d
Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule
RNA sequencing of E18.5 kidneys from glucocorticoid receptor (GR) null mice identified significant reductions in key ciliogenesis-related genes including Ccp110, Cep97, Cep290 and Kif3a. Confocal ...
ahajournals.org25d
Pathways and Molecular Mechanisms Governing LDL Receptor Regulation
Division of Cardiology, Department of Medicine, University of California, Los Angeles (H.M.S., K.E.J., T.Q.d.A.V., E.J.T.). Division of Cardiology, Department of ...
C&EN29d
Persistent Directed Flag Laplacian (PDFL)-Based Machine Learning for Protein–Ligand Binding Affinity Prediction
Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States ...