After earning notoriety as the first cellular receptor isolated and mammalian lectin identified, the Ashwell-Morell ...

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes ...

Scientists are aiming to determine the composition and topology of physiological Ashwell-Morell receptor ligands. Their ...

Estrogen-related receptors (ERRs) regulate muscle mitochondria in mice, revealing a new potential drug targets for metabolic ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) ...

Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function ...

of interaction with the CD4 receptor (yellow) represents a conserved accessible surface on HIV-1, and many commonly elicited antibodies compete with CD4 for binding to gp120. Various pathogens are ...

Understanding the allosteric regulation mechanisms of SP2509 may facilitate the development of new LSD1 inhibitors. Using SP2509 as a probe, two new binding modes are identified in this work, both of ...