New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa ...

Targeting CDC-like kinases 2 and 3 (CLK2 and CLK3) has emerged as an effective therapeutic strategy in cancer treatment, with several compounds currently in clinical development.

National Institutes of Health (NIH) scientists report that a first-in-human clinical trial of a new therapy based on the ...

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

Agency supports primary and novel secondary and exploratory endpoints proposed for Phase 3 Trial(s) Opportunity to utilize ...

Peptidomimetics are synthetic analogs that retain the essential structure and function of peptides but with chemical ...

Sharing a conserved structure comprised of 7 transmembrane α-helices, GPCRs couple to heterotrimeric G-proteins, GPCR kinases ... and angiotensin II receptors for heart failure and hypertension, and ...

Transmembrane signaling by plant receptor kinases (RKs) has long been thought to involve reciprocal ... Using a homology-guided approach, we designed mutations to stabilize the active-like ...