DNA methylation, RTK pathway changes, and KRAS amplifications may drive resistance to sotorasib plus panitumumab in KRAS G12C ...

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important factor from a complex downstream ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) ...

FMS-like tyrosine kinase 3 (FLT3) mutations represent some of the most pivotal genetic alterations in acute myeloid leukemia (AML), influencing ...

Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene ...

Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene ...

STPKs play critical roles in signalling pathways, such as the transforming growth ... 1986 Blk (B lymphocyte kinase) Tyrosine phosphorylation B-cell receptor signalling and development; insulin ...

One of the novel pathways under investigation is the inhibition of Bruton tyrosine kinase, a cytoplasmic tyrosine ... Involvement of Fc receptors in disorders of the central nervous system.

Domains and ligands of RTKs are illustrated in Table 1 respectively. Table 1. Growth factors of RTK [4]. 2. Receptor Tyrosine Kinase Pathway 2.1. MAP Kinase Pathway First, the mitogen activated ...

Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing, China Targeted therapy is a groundbreaking innovation for cancer treatment.