This landmark study describes the structure of the human RAD51 filament with a recombination intermediate called the displacement loop (D-loop). Using cryogenic structural, biochemical, and ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Life is thought to have begun when RNA began replicating itself, and researchers have got close to achieving this in the lab ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

Jacob Graham Baldwin, 27, died on Oct. 16, 2024, four days after a Saturday night altercation in Scott’s Addition. Baldwin was from Midlothian, in Chesterfield County. A grand jury has certified ...

The intermediate states occurring during nucleotide addition by HIV-1 RT remain unclear. Here, authors use cryo-EM to capture five unique states that show how a mobile catalytic Mg 2+ drives ...

Nucleic acids (DNA or RNA) are polymers of nucleotides – each nucleotide consists of a pentose sugar, a phosphate group and one of the nitrogenous bases (purines and pyrimidines). Nucleic acids ...

† China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory ...

Chemical Process R&D Department, Process Research Facility, The DuPont Pharmaceuticals Company, ‡ Deepwater, New Jersey 08023-0999, U.S.A. Article Views are the COUNTER-compliant sum of full text ...