Maeshima and colleagues propose that hubs of RNAPII and other components of the gene transcription machinery constrain chromatin movements by connecting different chromatin regions together into ...

Global analysis of active RNAPII reveals that hypoxia-inducible genes are paused and active prior to their induction. Our results provide a mechanistic link between HIF1A and CDK8, two potent ...

Notably, all RNAPII-transcribed genes in human cells undergo bursts of expression, punctuated by periods of inactivity. Our lab is using a variety of biochemical, cellular, and biophysical methods to ...

Based on this straightforward finding, the Stanford researchers constructed a dynamic equilibrium model for how cell size and RNAPII-powered transcription rates stay synced.

In vivoanalysis of RNAPII elongation shows that splicing does not alter elongation rates.

Transcription by the RNAPII enzyme takes place in several steps, each tightly controlled through the opposing functions of cyclin-dependent kinases (CDKs), which modify the enzyme by adding ...

RNAPII signals on histone genes also correlated with clinical grades in meningiomas, accurately predicting rapid recurrence as well as the tendency of whole-arm chromosome losses.

RNAPII signals on histone genes also correlated with clinical grades in meningiomas, accurately predicting rapid recurrence as well as the tendency of whole-arm chromosome losses.

RNAPII expression correlates with and predicts cancer aggressiveness To test their hypothesis, the researchers used CUTAC profiling to examine and map RNAPII, which transcribes DNA into precursors of ...

The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins.