In breast and colon samples in particular, they found high RNAPII occupancy centered over the gene that encodes human epidermal growth factor receptor 2 (HER2), an oncogene that is an attractive ...

In the study, published in Science, the researchers discovered that the amount of a specific enzyme, RNA Polymerase II (RNAPII), found on histone genes was associated with tumor aggressiveness and ...

RNAPII expression correlates with and predicts cancer aggressiveness To test their hypothesis, the researchers used CUTAC profiling to examine and map RNAPII, which transcribes DNA into precursors of ...

RNAPII signals on histone genes also correlated with clinical grades in meningiomas, accurately predicting rapid recurrence as well as the tendency of whole-arm chromosome losses.

RNAPII signals on histone genes also correlated with clinical grades in meningiomas, accurately predicting rapid recurrence as well as the tendency of whole-arm chromosome losses.

ChIP-sequencing revealed a reduction of RNAPII occupancy at promoter sites in EndMT compared to controls, suggesting the release of RNAPII during EndMT. Transcriptome-wide RNA elongation rates were ...

The SPARC complex directs accurate RNAPII positioning for transcription initiation and, in some instances, ensures correct transcription directionality in Trypanosoma brucei.

This histone modification permits recruitment of a memory-specific pre-initiation complex, poising RNAPII at the promoter. During memory, H3K4me2 is essential for recruitment of RNAPII and faster ...

The model was tested on both RNAPII and CTCF ChIA-PET data from human K562 and MCF7 and RNAPII and H3K9me2 ChIA-PET data from rice MH63. The performance of the proposed method was evaluated with the ...

RNAPII mutations that accelerate transcription cause auto‐immunity‐like phenotypes, read‐through transcription at RNAPII stalling sites and enhanced splicing in Arabidopsis, indicating that controlled ...

RNAPII and gene transcription activity are naturally reduced when cells enter a dormant state called quiescence or when their DNA is damaged by ultraviolet light.