RNA Biotechs: Current State And Outlook
RNA-based therapeutics are gaining traction due to advancements in delivery technologies, despite historical challenges with ...
IEEE25d
MMFmiRLocEL: A multi-model fusion and ensemble learning approach for identifying miRNA subcellular localization using RNA structure language model
Several computational methods have been proposed for measuring MSL. However, existing methods only rely on manually crafted features based on sequence without considering RNA 3D structure information, ...
gut.bmj27d
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. Design By utilising large scale ...
SciTech Daily1mon
Scientists Just Discovered an RNA That Repairs DNA Damage – And It’s a Game-Changer
A research team has identified NEAT1, a long non-coding RNA, as a key player in DNA repair ... which leads to changes in the NEAT1 secondary structure. As a result, highly methylated NEAT1 accumulates ...
Nature1y
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
In summary, the three-dimensional structure of HCV NS5B polymerase reveals the first complete view of a viral RNA-dependent RNA polymerase. The structure of NS5B significantly extends structural ...
Frontiers3y
Single-Cell RNA-seq Identification of the Cellular Molecular Characteristics of Sporadic Bilateral Clear Cell Renal Cell Carcinoma
Cellular molecular characteristics can be expressed at the RNA level, especially at the single-cell degree. Single-cell RNA sequencing (scRNA-seq) was performed on bilateral clear cell RCC (ccRCC). A ...
eLife5y
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
In this work, we characterize the phase diagram of tau-RNA LLPS using a combination of experiment and ... and that tau remains dynamic and without a persistent structure within the dense phase. The ...
Investopedia8y
Capital Structure Definition, Types, Importance, and Examples
She has 15+ years of experience as a financial writer and technical analyst. A firm's capital structure is a mix of borrowed money and investor funding that it uses to fund itself. When Meta ...
Frontiers10y
High temporal and spatial diversity in marine RNA viruses implies that they have an important role in mortality and structuring plankton communities
Amplicon deep-sequencing of the RNA dependent RNA polymerase (RdRp ... of RdRp gene fragments using 454 pyrosequencing revealed the richness and population structure of marine Picornavirales in five ...
eLife11y
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
Disrupting the junction’s fold eliminates the buildup of disease-related sfRNAs in human cells infected with a flavivirus, directly linking RNA structure to sfRNA production. More than 40% of people ...