This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

Researchers engineered a new gene system in the parasite A. deanei using a bacteriophage enzyme and novel drug markers. This ...

Despite the fact that RNA polymerase maintains the same key role in all living organisms, its structure, the principles of its work and functions diversify in prokaryotic and eukaryotic cells.

The prokaryotic form of RNA polymerase has four subunits capable of transcribing all types of RNA. In eukaryotes, these enzymes have eight or more subunits that facilitate the attachment and ...

Despite polα–primase being the first human polymerase discovered, the way it synthesizes very specific lengths of RNA and DNA in a single strand remained unclear for more than 50 years.

Five of these are core subunits which form crab claw shapes with DNA at their centres, channels for RNA products and NTP substrates as well as an additional 5 units. The claw like shape stabilizes ...

All modern organisms fall into two classes, eukaryotes and prokaryotes. Eukaryotes (from the Greek meaning "true kernel") have a cell nucleus that harbours most of the cell's genetic information and ...

Here, we show that the essential Spt5 processivity factor of RNA polymerase II (Pol II) plays a direct role in this process in budding yeast. Functional orthologues of eukaryotic Spt5 are present in ...

In the latest shake-up for scientific dogma, research has demonstrated that eukaryotic cells can convert RNA sequences back into DNA, through a misunderstood, ‘error-prone’ polymerase. Historically, ...

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells ... “The ...

Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells. Editor's Note: Thomas Jefferson University issued ...