The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA–DNA base-pairing to target foreign DNA in bacteria.

coli EndoV is equally active on both single- and double-stranded RNA. These are the novel findings implying a role for endonuclease V in RNA metabolism. Figure 1: Various incision activities for E.

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome ...

CRISPR–Cas13—a class 2 type VI RNA endonuclease with two higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domains for RNA cleavage—targets and degrades RNA. The RNA targeting has ...

The research is published in Nature, in the paper, “Fanzor is a eukaryotic programmable RNA-guided endonuclease.” People have long wondered whether systems similar to the well-known bacterial ...

Doudna is one of two corresponding authors of a paper in the journal Science describing this work titled "A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity." ...

Respiratory syncytial virus (RSV), SARS-CoV2, influenza virus, poliovirus, and measles—all single-stranded RNA viruses—are ... stress granules from an RNA endonuclease RNase L that cleave ...

The review paper "CRISPR Beyond: Harnessing Compact RNA-Guided Endonucleases for Enhanced Genome Editing," authored by Feizuo Wang from National University of Singapore, presents a comprehensive ...

RNA serves multiple functions in the body ... of the Fanzor proteins showed that they are DNA-cutting endonuclease enzymes that use nearby non-coding RNAs known as ωRNAs. These ωRNAs target ...

Richards first encountered endonuclease R during his postdoctoral fellowship at ... Roberts originally intended to focus on using restriction enzymes to sequence DNA, echoing the RNA sequencing ...