Here, we show that overexpression of RNase L decreases cellular growth and downmodulates the RNA-binding protein, HuR, a regulator of cell-cycle progression and tumorigenesis. The effect is ...

RNase L can form a heterodimer with the RNase L inhibitor protein (RLI) 16,17 and with an RNA-binding protein (RNABP) 18,19. The association of RNase L and RNABP has been observed in different ...

The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Molecular Cell , 2019; DOI: 10.1016/j.molcel.2018.11.034 Cite This Page : ...

In some systemic autoimmune diseases, antibodies target nuclear proteins bound ... that the efficacy of RNase-based treatments depends on the localization of the RNA-binding site,” says Ryota ...

An RNA-modifying enzyme passed to daughter cells during budding ... Discover Biotium’s new RNaseReveal™ Activity Assay Kit—ultrasensitive RNase detection with a fast, easy protocol to streamline your ...

Proteins that bind ... Mutations that abolish the DNA binding activity are frequently found in human cancers. However, it has been known that p53 also harbours RNA binding capacity but this ...

Study: Inborn errors of OAS–RNase L in SARS-CoV ... cytosolic proteins, which generate 2′-5′-linked oligoadenylate (2-5A) after binding to double-stranded (ds) RNA. In turn, the 2-5A ...

Led by Ryan Flynn, MD, PhD, assistant professor of stem cell and regenerative biology at Harvard Medical School (HMS), the study identified one RNA-binding protein on the cell surface, NPM1 ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology. As critical regulators of gene expression ...

A protein-RNA structure hints at how viruses commandeer human proteins Nov 11, 2015 RNA transport in neurons—Staufen2 detects its target transcripts in a complex manner ...

Mutations in or mislocalization of RNA-binding proteins, such as TDP-43 and FUS, are linked to protein aggregation in frontotemporal dementia and amyotrophic lateral sclerosis. Now, researchers led by ...