Key Findings • Infection by Pseudomonas aeruginosa conferred an increased risk for AMR among lung transplant recipients, particularly those with cystic fibrosis. • Using mouse models, researchers ...

After lung transplantation, infection with Pseudomonas aeruginosa independently predicted antibody-mediated rejection (AMR), researchers found. Through a series of mouse-model studies, the ...

Cystic fibrosis patients and patients with chronic obstructive pulmonary disease, trauma, burn wound, or patients requiring ventilation are susceptible to severe pulmonary infection by Pseudomonas ...

University of California San Diego and University of California Berkeley researchers have been awarded up to $7 million from the Advanced Research Projects Agency for Health (ARPA-H) to conduct ...

P. aeruginosa 's in vitro viability was lowered by 5.3 log 10, which had a disinfecting effect. Around 94% of the bacteria in the treated mice's lungs were removed. Notably, the nanohybrids could be ...

CEC124 challenged mice lungs were harvested on 1 day post infection or DPI (approximately 16 – 18 hours post infection or HPI), and mPa08-31 challenged mice lungs on 2 DPI. For mRNA seq analyses, ...

In patients with cystic fibrosis (CF), levels of serum immunoglobulin G1 (IgG1) against Pseudomonas aeruginosa antigens are elevated and linked to declining pulmonary function, according to findings ...

Reference: “Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms” by Rocco Mazzolini, Irene Rodríguez-Arce, Laia Fernández-Barat, ...

This research is published in Nature Biotechnology in the paper, “ Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms. ” P ...

They are toxins naturally produced by bacteria to kill or inhibit the growth Pseudomonas bacterial strains. To test its efficacy, they collected P. aeruginosa biofilms from the endotracheal tubes ...

Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms. Nature Biotechnology, 2023; DOI: 10.1038/s41587-022-01584-9 ...

Journal reference: Mazzolini, R., et al. (2023) Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms.