A new editorial perspective titled "Cancer-associated fibroblasts: challenges and opportunities" has been published in Oncotarget. Cancer-associated fibroblasts (CAFs) are a type of cell that ...

Cancer-associated fibroblasts (CAFs) are an important component in solid tumors. They play a decisive role in cancer development and have a significant influence on the success of therapy. The ...

Cancer-associated fibroblasts (CAFs) get a bad rap. The protective, gel-like complex surrounding tumors have been thought to be a no-go for drugs and are known to enforce treatment resistance.

Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma. CAFs enhance the malignant features of nearby cancer cells, increasing the likelihood of metastasis. P53 is a ...

Cancer-associated fibroblasts (CAFs) are crucial in melanoma metastasis, influencing tumor microenvironments and patient outcomes, especially in immunotherapy contexts. Single-cell RNA sequencing ...

A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

Many patients do not respond well to immunotherapy, said Professor Gareth Thomas, who led the study and has been examining the types of cells that surround tumors—cancer-associated fibroblasts ...

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

Researchers found that the Annexin A6 molecule contained in extracellular vesicles (EVs) is secreted by cancer-associated fibroblasts (CAFs) and taken up by gastric cancer cells, resulting in ...

Cancer-associated fibroblasts (CAFs) are an important component in solid tumors. They play a decisive role in cancer development and have a significant influence on the success of therapy.