A new study published in Nature reveals how olfactory sensory neurons (OSNs) achieve extraordinary precision in selecting ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.

In a new move, researchers have shown that protein design software can incorporate motion into its outputs. The resulting ...

In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new study shows that a ...

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs ... In contrast, ADAR1 and DHX9 suppress circRNA production by editing RNA sequences or destabilizing RNA structures.

Of these 65,855 sequences, only 676 have structures available in ... Similarly, the missing residues in PDB structures may also contribute to allosteric sites. The same protein binding to multiple ...

When located at an antigenic site, ST and FT peptides should ... We searched for canonical CaM-binding motifs within the sequences of all proteins for which we detected structural alterations upon CaM ...

This paper reviews studies that use machine learning to predict protein-ligand binding sites from sequence data, focusing on recent advancements. The review examines various embedding methods and ...

In this study, we explored sequences functioning as ribosome binding sites (RBSs) within protein coding DNA sequences (CDSs) that cause internal translation, resulting in truncated proteins.

2018 - link The work describes a variational autoencoder that can add metal binding sites to protein sequences, or generate protein sequences for a given protein topology. These instructions will get ...