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C&EN1d
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
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gut.bmj17d
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat
The aim of the present study was to examine the effects of calpain inhibitor I in rats subjected to experimental colitis. METHODS Colitis was induced in rats by intracolonic instillation of ...
C&EN4d
Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome
Thus, we hypothesize that mDia2 may have other unappreciated functions and regulatory modes. Here we identify and validate proteasome and Ubiquitin as mDia2-interacting partners using stable isotope ...
BMJ24d
The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus
charite.de Objectives To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with ...
thorax.bmj12d
Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury
In contrast, levels of secretory leukocyte protease inhibitor did not decrease over time. This decrease in elafin was due to cleavage by the 20S proteasome which was significantly increased in ALI ...
gut.bmj7d
Mediation by NF-κB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors
The role of NF-κB in ICAM-1 gene regulation was therefore examined by using different proteasome inhibitors in tumour necrosis factor α (TNF-α) stimulated IEC-6 rat intestinal epithelial cells.