Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites. Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma.

The pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories at three dosage strengths and oral syrup were studied. The study had an open-label, randomized ...

Thirty-seven subjects were enrolled, and 36 of them completed the study. After enrollment and completion of study period 1 (treatment D, 50 mg [10 mL] of promethazine oral syrup), one subject was ...