Miltefosine is an alkyllysophospholipid analogue drug with in vitro activity against the promastigote and amastigote stages of Leishmania species. It is already approved to treat visceral ...

During the Leishmania cell cycle ... however, if that promastigote enters an amastigote differentiation cell cycle, then the pro-basal body will nucleate a 9+0 flagellum. Therefore, from its ...

This marks the first approved drug for cutaneous or mucosal leishmaniasis ... of LdMT causes miltefosine resistance both in promastigote and amastigote forms that persists in vivo.

Leishmania parasites ... cycle has two stages: the promastigote, which is flagellate, extracellular, and found in the sandfly that transmits the protozoan; and the amastigote, which is ...

These cells are in the amastigote life cycle stage; the life cycle stage normally found inside macrophages (a type of white blood cell) inside a person. Leishmania parasites are transmitted through ...