Proliferation of CLL cells is restricted to this protective niche, but the underlying mechanism(s) is/are not known. Treatment with BCR pathway inhibitors results in rapid reductions of total ...

Atacicept, an investigational BAFF (B-cell activating factor)/APRIL (a proliferation-inducing ligand) dual inhibitor, significantly reduced proteinuria in patients with immunoglobulin A nephropathy ...

A megakaryocyte CFU assay was performed in five patients. It showed substantial inhibition of spontaneous proliferation at 1 month after initiation of imetelstat treatment, with a median 92% ...

A research team has developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant ...

Researchers led by Université de Montréal pathology and cell-biology professor Marc Therrien have identified major structural ...

Everolimus, a novel proliferation inhibitor and immunosuppressive agent, may suppress cardiac-allograft vasculopathy. We conducted a randomized, double-blind, clinical trial comparing everolimus ...

(B) Flow cytometer analysis showed that human B-lymphoma cells underwent apoptosis after CREB inhibitor treatment. (D) Western blot experiment demonstrates the efficacy of CREB antibody ...

This proliferation of "me-too" drugs is expensive ... Manufacturers making claims about "developing 'a better' checkpoint inhibitor should directly compare their agent with those that are already ...

In some forms of cancer, these enzymes are present in high levels or overactive and inhibiting them can prevent the proliferation of cancer cells. Tyrosine kinase inhibitors therefore provide an ...

In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape drug-induced quiescence through a nongenetic manner of adaptation and resume slow proliferation. Here, we ...

"To limit that toxicity, we thought we'd try to identify other drugs that could synergize with LSD1 inhibitors to overcome the differentiation arrest and suppress the proliferation of cancer cells." ...