Remember the time when the only way to alter expression of an endogenous gene in eukaryotes was to knock ... For researchers working with prokaryotes it is now 1998. Bacteria do not have a ...

On May 12, 2025, the Court of Appeals for the Federal Circuit vacated-in-part and remanded a Patent Trial and Appeal Board (“PTAB”) decision in ...

On May 12, 2025, the U.S. Court of Appeals for the Federal Circuit issued a long-awaited decision in Regents of the University of California v.

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

Replicative DNA polymerases (Pol) function with a sliding clamp and their proofreading exonuclease provides high fidelity. Thus, the study of the proofreading mechanism must both contain the Pol–clamp ...

Meiotic recombination is an evolutionary-conserved process that shapes genetic variation in most eukaryotes. DNA is packaged into nucleosomes, and high levels of nucleosome occupancy suppress ...

Algae, plants, and animals are known as Eukaryotes, meaning they have membrane-bound nuclei. NC does not have membrane-bound nuclei and therefore gets to be classified as a Prokaryote. With that out ...

This manuscript reports findings of fundamental significance on how bacteria might load helicase for DNA replication when normal DnaA-based loading pathway is defective. It provides convincing genetic ...