Prions, mysterious shape-shifting proteins, can lead to brain disorders such as Creutzfeldt-Jakob disease in humans and ...

"It has long been questioned whether the diversity in prion strains may depend on the glycans that compose them as well as on protein folding. Our results led us to an answer for the first time." ...

Solution NMR studies of recombinant prion proteins from four species 5,6,7,8 gave similar, predominantly α-helical, monomeric folds which were presumed to represent the PrP C structure.

Groundbreaking research from the University of Alberta has identified the structure of the infectious prion protein, the cause of "mad cow disease" or BSE, chronic wasting disease in deer and elk ...

In a study published earlier in January, researchers in the lab of Jose Rodriguez, assistant professor of chemistry and biochemistry, determined the structure of a segment of prion, a protein that ...

This altered water structure influences the protein's ability to adopt its abnormal shape. The study, "Water-directed pinning is key to tau prion formation," is published in the Proceedings of the ...

The structure argues against existing theories ... Infectious prions or PrPSc -- misfolded versions of the normal cellular prion protein PrPC -- convert their normal counterparts into copies ...

The key event that kicks off prion formation and disease is the conversion of a normal protein – often PrP – into a prion structure. It’s not yet clear what prompts this change, but numerous gene ...

"For a better understanding of the mechanism of the diseases and the existence of strains, resolving the structure of the prion protein is necessary" neuroscientist Natali Naki?, first author of ...

Groundbreaking research from the University of Alberta has identified the structure of the infectious prion protein, the cause of "mad cow disease" or bovine spongiform encephalopathy (BSE), chronic ...

Prions transmit their abnormally folded ... This altered water structure influences the protein's ability to adopt its abnormal shape. The study will be published during the week of April 28 ...