Researchers have developed an AI system capable of predicting whether and why proteins form sticky clumps, a process ...

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, ...

Prions, mysterious shape-shifting proteins, can lead to brain disorders such as Creutzfeldt-Jakob disease in humans and ...

Familial prion diseases are due to dominantly inherited, germline mutations in the PRNP gene that encodes the prion protein (PrP). The cellular mechanism underlying the pathogenic effect of these ...

Disease-associated prion protein (PrP Sc) accumulates in FDCs (ref. 6), which function as antibody- and complement-dependent antigen traps. Here we investigated whether the mechanisms by which ...

Contribution from the Dipartimento di Chimica, Università di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy, European Laboratory for Nonlinear Spectroscopy (LENS), Via Nello Carrara ...

Structure-function relationships of biological macromolecules, in particular proteins, provide crucial insights for fundamental biochemistry, medical research and early drug discovery. However, ...

Education Ministry Key Laboratory on Luminescence Real-Time Analysis, College of Chemistry and Chemical Engineering, College of Life Science, and College of Pharmaceutical Sciences, Southwest ...

Most of the existing methods only use the protein sequence but ignore the three-dimensional structure which is closely related to the protein function. And the hierarchy of protein functions is not ...

First discovered in 2001, the protein PINK1 has been directly linked to Parkinson ... researchers from the Walter and Eliza Hall Institute of Medical Research (WEHI) have determined the structure of ...

In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in vitro do not possess the cross β‐structure of ...