Misfolded, prion-like proteins drive the progression of tauopathies ... role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related ...

Researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. Iowa State University ...

AMES, Iowa – Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion ...

A prime example of proteins that catalyze their own conformational change into the toxic form is the prion proteins ... to the prevention of protein misfolding. Despite chaperone actions, some ...

Tauopathies are neurodegenerative diseases driven by tau protein misfolding and subsequently accumulating into dense, ordered fibrils. These tauopathies are prion-like, meaning that misfolded tau ...

As the disease progresses, the brain takes on a sponge-like perforated structure and shows protein deposits. "The disease is triggered by the misfolding of the cellular prion protein, PrP for ...

Misfolded, prion-like proteins drive the progression of tauopathies ... role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related ...

Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. The ...