PharmiWeb6d
NuCana Reports Fourth Quarter and Year-End 2024 Financial Results and Provides Business Update
NuCana plc (NASDAQ: NCNA) announced financial results for the fourth quarter and year ended December 31, 2024 and provided an update on its clinical development program with its two lead anti-cancer ...
Frontiers20d
Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages
Alternative polyadenylation in the 3’UTR (3’UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, particularly in cancer and activated immune cells. Yet, how ...
Frontiers3y
Expression Elements Derived From Plant Sequences Provide Effective Gene Expression Regulation and New Opportunities for Plant Biotechnology Traits
Figure 7. GST7 enables effective expression that is dependent on functional polyadenylation and cleavage signals. Expression of GUS reporter genes with Zm.GST7 and its NUE polyadenylation signal and T ...
eLife4y
Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in ...
eLife5y
Tgfβ signaling is critical for maintenance of the tendon cell fate
Studies of cell fate determination are in most cases focused on the signaling pathways and transcription factors that direct naive cells to assume a specific cell fate (Li et al., 2012; James, 2013; ...