ABSTRACT: Background: Malaria is the leading cause of hospital admission in Africa and constitutes the greatest disease burden in the region. More than one hundred nations are affected worldwide with ...

They included five patients and their living kidney donors: three with rFSGS, two without symptoms, and one (P5) with NPHS2 heterozygous mutations. Peripheral blood mononuclear cells were reprogrammed ...

Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10–30% of pediatric cases of steroid resistant nephrosis and/or FSGS. Methods. We studied the spectrum of ...

Based on this study, it was found that berberine treatment could reduce podocyte injury by downregulating TGF-β1 receptor expression, which reduced apoptosis and increased podocyte adhesion ability ...