The membrane-oriented processes of subendothelial adhesion of platelets, granule release, cohesion, aggregation, and plug stabilization involve several well-characterized ligand–receptor ...

Platelet activation is a complex and dynamic process, involving the co-ordination of numerous receptors to initiate shape change and aggregation. Under pathological conditions, alterations in the ...

Another potential source for improvements in medical care comes from the recent introduction of specific drugs that target other platelet receptors. Agents that target two such receptors are in ...

These autoantibodies target platelets for destruction by macrophages in the spleen, liver, or both through activation of Fcγ receptors; this process is controlled by spleen tyrosine kinase (Syk).

Activation of platelets is triggered by direct adhesion of the parasites to platelet receptors, in addition to other stimuli, such as increased levels of CRP. After contact with parasites ...

The research team developed antibody fragments called nanobodies and crosslinked these to make ligands to four platelet receptors (GPVI, CLEC-2, FcɣRIIA and PEAR1). The nanobodies can be used to ...

Interaction of two platelet receptors leads to cerebral venous thrombosis Until now, the molecular processes involved in the development of cerebral venous thrombosis were poorly understood ...

CXCL4 binds directly to gp120 and blocks viral entry into T cells irrespective of co-receptor requirements. Scientists have identified a platelet-derived chemokine that naturally inhibits ...

Integrin αIIβ3 is a platelet receptor that is necessary for platelets to clump together in the blood (called platelet aggregation). Platelet aggregation can cause vessel occlusion that blocks ...