The authors confirm that telomeres in telomerase-positive cells terminate with 5'-ATC in a Pot1-dependent manner, and demonstrate that this principle holds true in telomerase-negative ALT cells as ...

The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

The NCBI Prokaryotic Genome Annotation Pipeline is designed to annotate bacterial and archaeal genomes (chromosomes and plasmids). Genome annotation is a multi-level process that includes prediction ...

coli populations demonstrated that reducing entropy promoted the effective plasmid transfer rate. Analysis of prokaryotic genome data suggested that plasmids and antibiotic resistance genes were ...

When representing the evolution of the average protein lengths versus their corresponding gene lengths across different species, it is observed that they evolve simultaneously in prokaryotes ...

While biofilms may serve as a reservoir for antibiotic resistance carried by conjugative plasmids, they might not be a structure acquiring resistance easily. Our study provides insights into the ...

Accurate placement of the division septum at the midpoint of Escherichia coli cells requires the combined action of a general division inhibitor (MinC), a site-specific suppressor of division ...

In the nucleus of eukaryotic cells, DNA is almost exclusively found in ... For experiments involving recovery of circular plasmids, pDONR223_MYC_WT (RRID:Addgene82927) and ALK_pLenti (recombined ...

Prokaryote mobilome genomes rely on host machineries for survival and replication. Given that mobile genetic elements (MGEs) derive their energy from host cells, we investigated the diversity of ...