Host defense against pathogens is essential to restrict infectious diseases, and understanding the underlying biology is paramount to the development of new treatment strategies. This exciting ...

One key defense strategy involves recognizing pathogen-associated molecular patterns (PAMPs), which are distinctive molecules that signal the presence of microbial intruders. Among the most important ...

One key defense strategy involves recognizing pathogen-associated molecular patterns (PAMPs), which are distinctive molecules that signal the presence of microbial intruders. Among the most ...

Functional enrichment analysis revealed that these genes are primarily associated with the PI3K-Akt and B-cell ... In summary, our study clarifies the common molecular mechanisms underlying SLE and PD ...

7IU Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana. 11Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis ...

A series of intracellular receptors detect microbial pathogen-associated molecular patterns, and have probably evolved to combat both viral and bacterial pathogens. Although cytosolic pathogens ...

They can dynamically tune their phenotype in response to the changing combination of cytokines and pathogen-associated molecular patterns (PAMPs) present during an infection. Macrophages can switch ...

We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter ...