Researchers at Umeå University have investigated the connective tissue cells that surround the cancer cells in pancreatic cancer. These cells, called cancer-associated fibroblasts (CAF), play an ...

The relationship the immune system and stromal cells in pancreatic cancer can have a significant impact on patients' survival rates, according to findings of a Queen Mary-led study. Pancreatic ...

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...

"The stroma is considered a key component in the aggressive nature of pancreatic cancer, as it interacts with tumor cells, protects them, and hinders the action of drugs. Moreover, stromal cells, ...

Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors. The newly discovered cells counteract ...

Pancreatic cancer is known for its reputation of being harder to detect in its earliest stages,” said J. Bart Rose, M.D., an ...

pancreatic tumors exhibit adaptive resistance mechanisms. Some cancer cells circumvent GOT2 loss through macropinocytosis or by acquiring metabolites from cancer-associated fibroblasts ...

Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties. Cancer Research , 2025; DOI: 10.1158 ...

A previously unknown subgroup of cancer-associated fibroblasts (ifCAF) in pancreatic tumors has been identified, which can inhibit tumor growth and facilitate immune cell attack on cancer cells.