Use of two separate pattern recognition receptor (PRR) agonists as adjuvants in vaccine formulations has shown to enhance the immune response against the antigen. The limitation with the use of two ...

Middle (Canonical): PRRs detect PAMPs or DAMPs, triggering inflammasome assembly (PRR, ASC, and pro-caspase-1). Active caspase-1 cleaves GSDMs, generating GSDMs-NT and inducing pyroptosis. Right ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by ...

In the final episode, experts at UCSD and La Jolla Institute discuss current clinical trials of a cancer vaccine and future directions for neoantigen vaccines. Custom-made Cancer Therapy ...

March 20 (Reuters) - Sanofi (SASY.PA), opens new tab on Thursday announced an agreement with biopharmaceutical company Dren Bio for the acquisition of its autoimmune disease treatment DR-0201. The ...

These universities have shown strength in producing research related to immunology, which is the study of the human body's defense system. Students in this field study infectious diseases ...

Apr. 10, 2025 — Research has shed light on how a new type of antibody treatment reactivates patients' immune cells to fight ovarian ... New Phase of the Immune Response Uncovered Apr. 10, 2025 ...

2 PRRs detect both MAMPs and effector molecules. The PRR family includes receptor-like proteins (RLP) and receptor-like kinases (RLK). RLK is structurally similar to receptor-tyrosine kinases ...

The independent Performance Review Commission (PRC) has just released its Performance Review Report 2024, evaluating European Air Traffic Management (ATM) performance across a wide spectrum of key ...

Four algorithms (ROR, PRR, BCPNN and EBGM) were used to detect sulfasalazine-correlated AE signals in real data to calculate the signals associated with sulfasalazine-related AEs. During the study ...