His work tries to decipher the mechanisms and factors that cells use to prevent and resolve harmful R-loops and transcription-replication conflicts, in particular the mechanisms involving factors of ...

Conversely, the downregulated pathways included: Aminoacyl-tRNA biosynthesis, Cell cycle, DNA replication, Fanconi anemia pathway, Homologous recombination, Mismatch repair, Nucleocytoplasmic ...

Nurses and other healthcare workers in Northern Ireland have called to consign the NHS Pay Review Body (PRB) process “to the history books where it belongs” following many years of pay delays. Health ...

This study presents an important finding that the activation of TFEB by sulforaphane (SFN) could promote lysosomal exocytosis and biogenesis in NPC, suggesting a potential mechanism by SFN for the ...

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, China; Department of Molecular, Cellular, ...

The new molecule, called lariocidin, works by targeting a part of a bacteria’s cell called the ribosome and can disrupt the cell’s functions. "This is a new molecule with a new mode of action.

Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

We've identified the following companies as similar to Bombardier Inc Pref B because they operate in a related industry or sector. We also considered size, growth, and various financial metrics to ...

Cholesterol is critical for mitochondrial membrane structure and function. Given the emergence of mitochondria as a key factor in the pathogenesis of heart failure, mitochondrial cholesterol ...

Mechanistic studies revealed that the mito-condition medium activates the AMPK pathway, a crucial cellular energy sensor, driving upregulation of mitochondrial biogenesis genes such as TFAM.