Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions often ...

He referenced preclinical data, mostly about first-generation drugs, that indicated GLP-1 agonists may promote bone formation by increasing osteoblast differentiation and survival while reducing ...

However, whether CCL19 and CCL21 chemokines have any role in the regulation of osteoclast differentiation or activation has not yet been investigated. Objectives The purpose of this study was to ...

Osteogenic differentiation is essential for bone development, metabolism, and repair; however, the underlying regulatory relationships among genes remain poorly understood. To elucidate the ...

Abnormalities in the differentiation process can lead to consequences, such as impaired tissue regeneration and the development of certain cancers. Led by Lars Velten, PhD, group leader at the ...

Feb. 27, 2025 — Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

Importantly, RANKL and RANK are essential for the development and activation of osteoclasts and bone loss in response to virtually all triggers tested. Therapeutically, inhibition of RANKL function ...