Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

Osteoblasts (bone-forming cells) and osteoclasts. Osteoclasts are large multinucleated cells with a myeloid lineage, which have the function of clearing away mineralized and calcified constituents ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering ...

Bortezomib may increase osteoblast activity but it is unclear ... agents alter abnormal bone metabolism in MM, inhibiting osteoclast function. Novel agents under evaluation, targeting the RANKL ...

Osteoblasts and osteoclasts are two types ... indicating its cytoplasmic function in osteoclast differentiation. Further, ...

A scale also has cells corresponding to osteoblasts and osteoclasts. Scales protect the surface of the fish body and play a role as a reservoir of calcium. With freshwater fish, the latter function is ...

Although, bone remodeling by osteoblasts and osteoclasts is crucial for maintaining ... "Our study shows Gprc5a may function as a negative feedback factor for the bone formation promoting effect ...

The function of osteoblasts is dramatically ... these events would shift the balance between osteoblasts and osteoclasts in favor of osteoclasts, thereby diminishing bone formation and enhancing ...

Osteoblasts and osteoclasts are two types ... indicating its cytoplasmic function in osteoclast differentiation. Overall, these findings provide novel insights into the process of osteoclast ...