This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Based upon a successful engagement with the US Food and Drug Administration (FDA) at the End-of-Phase 2 meeting in January ...

Clinical data highlight survival benefits and improvement in functional motor outcomes associated with treatment with doxecitine (dC) and ...

The metabolomic analysis revealed enriched nucleotide, amino acid metabolism (mainly methionine cycle and glycine metabolism), glucose metabolism, and lipid metabolism. In addition, transcriptomic ...

These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide excision repair (NER). NER in human cells is a complex ...

All this in addition to the cancellation of a government contract to service the police helicopter fleet, which has now been handed to an Ipoh-based company. A letter from the government to the ...

Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, United States Department of Biochemistry and Structural Biology, University of ...

In addition to comprehensively reviewing this field ... In the following sections, we review critically the evidence that canonical and noncanonical actions of guanine nucleotide exchange factors ...