Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During ...

The latest imaging method from the Broad Institute uncovers structural disruptions in the nucleus associated with progeria at ...

An ancient DNA study co-authored by Brown archaeologist Peter van Dommelen illustrates the complexity of human migration and ...

(74) Ketterer et al. mimicked the nuclear pore complex using DNA origami rings modified with the proteins in the natural nuclear pore complex. In this study, the authors characterized the ...

The approach is demonstrated by its application to the assembly process of the nuclear pore complex in the context of the nuclear ... Finally, these snapshot models are selected and connected into a ...

We use this system to calculate kinetic constants for passive diffusion across the nuclear pore and demonstrate single-cell heterogeneity ... induced localization of BRD4 to cytosolic-localized ...

Several types of cancer are believed to be linked to alterations of macromolecular structures known as nuclear pore complexes (NPCs ... enable the synthesis of DNA. Whether NPC alterations ...

researchers have been fascinated by the three-dimensional structure and function of these nuclear pores, which act as guardians of the genome: substances that are required for controlling the cell are ...

The compartmentalisation of the genome in eukaryotes both safeguards the DNA and permits more intricate regulatory ... that separates the nucleus from the rest of the cell. Nuclear pore complexes ...

“Nuclear pores” sounds like something from a skincare video. But for cell biologists, they’re a decades-long enigma. “NPCs are essential for life,” explained Dr. Francis Collins, a former director at ...