Lesions can be modified bases as recognized by BER and NER or normal bases paired with wrong ... the mechanism of detecting broken DNA ends is beyond the scope of this review.

After solving the structure of Ku bound to DNA, Goldberg and his colleagues could see how the Ku heterodimer manages to “find” a broken DNA end regardless of its sequence. “The problem is ...

6-4PPs occur less frequently than CPDs and distort the helical structure of DNA more severely ... dimer and in a ternary complex with normal DNA. Complementing these structures, two residues ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published ...

The code within our DNA provides directions on how to make proteins that are vital for our growth, development, and overall health. Keep reading to discover more about the structure of DNA ...

Maintaining heterochromatin structure is necessary to the normal growth and functions of ... proteins rebuild the broken DNA into a copy of the sequence that was originally damaged; in this ...

Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect ... this protective structure at the ...

Researchers uncover how rapid DNA repair protects genomes from internal threats, with implications for cancer biology.

illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By unveiling Pol-theta's DNA-bound structure—its active state—the study provides a ...

The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped ... prevents telomerase from interfering with DNA repair under normal circumstances. He ultimately found ...