As part of gameplay footage for Nobunaga's Ambition: Awakening, the game's producer Michi Ryu produces a USB mouse, plugs it into the Switch 2 and starts using it alongside a Joy-Con.

Nintendo Switch 2 supports traditional USB mouse controls This was revealed in a presentation for Nobunaga's Ambition: ...

The Nintendo Switch 2 has been confirmed to have USB mouse support, pairing alongside the Joy-Con 2 controllers that can be switched to mouse mode.